• 5583 Citations
  • 25 h-Index
20022020

Research output per year

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Research Output

2020

Intranasal delivery of cancer-targeting doxorubicin-loaded PLGA nanoparticles arrests glioblastoma growth

Chung, K., Ullah, I., Kim, N., Lim, J., Shin, J., Lee, S. C., Jeon, S., Kim, S. H., Kumar, P. & Lee, S. K., 2020 Jul 2, In : Journal of Drug Targeting. 28, 6, p. 617-626 10 p.

Research output: Contribution to journalArticle

Nose-to-Brain Delivery of Cancer-Targeting Paclitaxel-Loaded Nanoparticles Potentiates Antitumor Effects in Malignant Glioblastoma

Ullah, I., Chung, K., Bae, S., Li, Y., Kim, C., Choi, B., Nam, H. Y., Kim, S. H., Yun, C. O., Lee, K. Y., Kumar, P. & Lee, S. K., 2020 Apr 6, In : Molecular Pharmaceutics. 17, 4, p. 1193-1204 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Targeted Delivery of Recombinant Heat Shock Protein 27 to Cardiomyocytes Promotes Recovery from Myocardial Infarction

Kim, N., Kim, N., Ullah, I., Ullah, I., Chung, K., Chung, K., Lee, D., Lee, D., Cha, M. J., Ban, H., Ban, H., Choi, C. S., Choi, C. S., Kim, S., Kim, S., Hwang, K. C., Kumar, P. & Lee, S-K., 2020 Jun 1, In : Molecular Pharmaceutics. 17, 6, p. 2034-2043 10 p.

Research output: Contribution to journalArticle

2019

A positioning device for the placement of mice during intranasal sirna delivery to the central nervous system

Ullah, I., Chung, K., Beloor, J., Lee, S. K. & Kumar, P., 2019 Aug, In : Journal of Visualized Experiments. 2019, 150, e59201.

Research output: Contribution to journalArticle

2018

Intranasal delivery of a Fas-blocking peptide attenuates Fas-mediated apoptosis in brain ischemia

Ullah, I., Chung, K., Oh, J., Beloor, J., Bae, S., Lee, S. C., Lee, M., Kumar, P. & Lee, S. K., 2018 Dec 1, In : Scientific reports. 8, 1, 15041.

Research output: Contribution to journalArticle

2 Scopus citations

Small Interfering RNA-Mediated Control of Virus Replication in the CNS Is Therapeutic and Enables Natural Immunity to West Nile Virus

Beloor, J., Maes, N., Ullah, I., Uchil, P., Jackson, A., Fikrig, E., Lee, S. K. & Kumar, P., 2018 Apr 11, In : Cell Host and Microbe. 23, 4, p. 549-556.e3

Research output: Contribution to journalArticle

6 Scopus citations
2017

Trileucine residues in a ligand-CPP-based siRNA delivery platform improve endosomal escape of siRNA

Ullah, I., Chung, K., Beloor, J., Kim, J., Cho, M., Kim, N., Lee, K. Y., Kumar, P. & Lee, S. K., 2017 Apr 21, In : Journal of Drug Targeting. 25, 4, p. 320-329 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Silencing CCR2 in Macrophages Alleviates Adipose Tissue Inflammation and the Associated Metabolic Syndrome in Dietary Obese Mice

Kim, J., Chung, K., Choi, C., Beloor, J., Ullah, I., Kim, N., Lee, K. Y., Lee, S. K. & Kumar, P., 2016 Jan 1, In : Molecular Therapy - Nucleic Acids. 5, p. e280

Research output: Contribution to journalArticle

17 Scopus citations
2015

Attachment of cell-binding ligands to arginine-rich cell-penetrating peptides enables cytosolic translocation of complexed sirna

Zeller, S., Choi, C. S., Uchil, P. D., Ban, H. S., Siefert, A., Fahmy, T. M., Mothes, W., Lee, S. K. & Kumar, P., 2015 Jan 22, In : Chemistry and Biology. 22, 1, p. 50-62 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Cationic cell-penetrating peptides as vehicles for siRNA delivery

Beloor, J., Zeller, S., Choi, C. S., Lee, S-K. & Kumar, P., 2015 Jan 1, In : Therapeutic Delivery. 6, 4, p. 491-507 17 p.

Research output: Contribution to journalReview article

13 Scopus citations

Effective gene delivery into human stem cells with a cell-targeting peptide-modified bioreducible polymer

Beloor, J., Suresh, R., Nam, K., Seon Choi, C., Kim, J., Kim, S. H., Cho, H. J., Shin, H., Kim, H., Kim, S. W., Lee, S-K. & Kumar, P., 2015 May 6, In : Small. 11, 17, p. 2069-2079 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Liver-targeted cyclosporine A-encapsulated poly (lactic-co-glycolic) acid nanoparticles inhibit hepatitis C virus replication

Jyothi, K. R., Beloor, J., Jo, A., Nguyen, M. N., Choi, T. G., Kim, J. H., Akter, S., Lee, S. K., Maeng, C. H., Baik, H. H., Kang, I., Ha, J. & Kim, S. S., 2015 Jan 30, In : International Journal of Nanomedicine. 10, p. 903-921 19 p.

Research output: Contribution to journalArticle

16 Scopus citations
2014

Arginine-grafted biodegradable polymer: A versatile transfection reagent for both DNA and siRNA

Beloor, J., Nam, H. Y., Lee, S-K. & Kumar, P., 2014 Jan 1, Cancer Genomics and Proteomics: Methods and Protocols. Humana Press Inc., p. 115-126 12 p. (Methods in Molecular Biology; vol. 1176).

Research output: Chapter in Book/Report/Conference proceedingChapter

Arginine-grafted biodegradable polymer: A versatile transfection reagent for both DNA and siRNA

Beloor, J., Nam, H. Y., Lee, S-K. & Kumar, P., 2014 Jan 1, Cancer Genomics and Proteomics: Methods and Protocols. Humana Press Inc., p. 115-126 12 p. (Methods in Molecular Biology; vol. 1176).

Research output: Chapter in Book/Report/Conference proceedingChapter

Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA

Ramakrishna, S., Kwaku Dad, A. B., Beloor, J., Gopalappa, R., Lee, S. K. & Kim, H., 2014 Jun, In : Genome Research. 24, 6, p. 1020-1027 8 p.

Research output: Contribution to journalArticle

300 Scopus citations
2013

Injectable microsphere/hydrogel hybrid system containing heat shock protein as therapy in a murine myocardial infarction model

Lee, J., Cha, M. J., Lim, K. S., Kim, J. K., Lee, S. K., Kim, Y. H., Hwang, K. C. & Lee, K. Y., 2013 Nov 1, In : Journal of Drug Targeting. 21, 9, p. 822-829 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Preparation and characterization of nonaarginine-modified chitosan nanoparticles for siRNA delivery

Park, S., Jeong, E. J., Lee, J., Rhim, T., Lee, S. K. & Lee, K. Y., 2013 Jan 30, In : Carbohydrate Polymers. 92, 1, p. 57-62 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Sequential delivery of TAT-HSP27 and VEGF using microsphere/hydrogel hybrid systems for therapeutic angiogenesis

Shin, S. H., Lee, J., Lim, K. S., Rhim, T., Lee, S. K., Kim, Y. H. & Lee, K. Y., 2013 Feb 28, In : Journal of Controlled Release. 166, 1, p. 38-45 8 p.

Research output: Contribution to journalArticle

29 Scopus citations
2012

Arginine-engrafted biodegradable polymer for the systemic delivery of therapeutic siRNA

Beloor, J., Choi, C. S., Nam, H. Y., Park, M., Kim, S. H., Jackson, A., Lee, K. Y., Kim, S. W., Kumar, P. & Lee, S-K., 2012 Feb 1, In : Biomaterials. 33, 5, p. 1640-1650 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

Cell-specific siRNA delivery by peptides and antibodies

Lee, S. K., Siefert, A., Beloor, J., Fahmy, T. M. & Kumar, P., 2012, Methods in Enzymology. Academic Press Inc., p. 91-122 32 p. (Methods in Enzymology; vol. 502).

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations

T cell-specific siRNA delivery using antibody-conjugated chitosan nanoparticles

Lee, J., Yun, K. S., Choi, C. S., Shin, S. H., Ban, H. S., Rhim, T., Lee, S. K. & Lee, K. Y., 2012 Jun 20, In : Bioconjugate Chemistry. 23, 6, p. 1174-1180 7 p.

Research output: Contribution to journalArticle

51 Scopus citations
2011

Blockade of the Wnt/β-catenin pathway attenuates bleomycin-induced pulmonary fibrosis.

Kim, T. H., Kim, S. H., Seo, J. Y., Chung, H., Kwak, H. J., Lee, S. K., Yoon, H. J., Shin, D. H., Park, S. S. & Sohn, J. W., 2011 Jun 20, In : The Tohoku journal of experimental medicine. 223, 1, p. 45-54 10 p.

Research output: Contribution to journalArticle

83 Scopus citations

Oligoarginine-modified chitosan for siRNA delivery.

Park, S., Lee, S. K. & Lee, K. Y., 2011 Nov 30, In : Journal of controlled release : official journal of the Controlled Release Society. 152 Suppl 1, p. e165-166

Research output: Contribution to journalArticle

7 Scopus citations
2010

Facile control of porous structures of polymer microspheres using an osmotic agent for pulmonary delivery

Lee, J., Oh, Y. J., Lee, S-K. & Lee, K. Y., 2010 Aug 1, In : Journal of Controlled Release. 146, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

87 Scopus citations

Targeted delivery of small interfering RNA to human dendritic cells to suppress dengue virus infection and associated proinflammatory cytokine production

Subramanya, S., Kim, S. S., Abraham, S., Yao, J., Kumar, M., Kumar, P., Haridas, V., Lee, S. K., Shultz, L. D., Greiner, D., Manjunath, N. & Shankar, P., 2010 Mar, In : Journal of Virology. 84, 5, p. 2490-2501 12 p.

Research output: Contribution to journalArticle

74 Scopus citations

The effect of spacer arm length of an adhesion ligand coupled to an alginate gel on the control of fibroblast phenotype

Lee, J. W., Park, Y. J., Lee, S. J., Lee, S. K. & Lee, K. Y., 2010 Jul 1, In : Biomaterials. 31, 21, p. 5545-5551 7 p.

Research output: Contribution to journalArticle

38 Scopus citations
2009

Conditional RNAi: Towards a silent gene therapy

Lee, S-K. & Kumar, P., 2009 Jul 2, In : Advanced Drug Delivery Reviews. 61, 7-8, p. 650-664 15 p.

Research output: Contribution to journalReview article

34 Scopus citations
63 Scopus citations

Delivering antiviral siRNA into human T-cells: New approaches in RNAi-based HIV therapy

Ban, H. S., Lee, S-K. & Kumar, P., 2009 Dec 1, In : IDrugs. 12, 12, p. 774-778 5 p.

Research output: Contribution to journalReview article

1 Scopus citations

Preparation and characterization of chitosan/polyguluronate nanoparticles for siRNA delivery

Lee, D. W., Yun, K. S., Ban, H. S., Choe, W., Lee, S. K. & Lee, K. Y., 2009 Oct 15, In : Journal of Controlled Release. 139, 2, p. 146-152 7 p.

Research output: Contribution to journalArticle

73 Scopus citations

The heat shock protein 27 (Hsp27) operates predominantly by blocking the mitochondrial-independent/extrinsic pathway of cellular apoptosis

Tan, C. Y., Ban, H., Kim, Y. H. & Lee, S. K., 2009 Jun 12, In : Molecules and Cells. 27, 5, p. 533-538 6 p.

Research output: Contribution to journalArticle

22 Scopus citations
2008

Effective suppression of HIV-1 by artificial bispecific miRNA targeting conserved sequences with tolerance for wobble base-pairing

Son, J., Uchil, P. D., Kim, Y. B., Shankar, P., Kumar, P. & Lee, S-K., 2008 Sep 19, In : Biochemical and Biophysical Research Communications. 374, 2, p. 214-218 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice

Kumar, P., Ban, H. S., Kim, S. S., Wu, H., Pearson, T., Greiner, D. L., Laouar, A., Yao, J., Haridas, V., Habiro, K., Yang, Y. G., Jeong, J. H., Lee, K. Y., Kim, Y. H., Kim, S. W., Peipp, M., Fey, G. H., Manjunath, N., Shultz, L. D., Lee, S. K. & 1 others, Shankar, P., 2008 Aug 22, In : Cell. 134, 4, p. 577-586 10 p.

Research output: Contribution to journalArticle

446 Scopus citations

TGFβ plasmid construction and delivery for the prevention of type 1 diabetes

Park, L., Lee, E., Lee, S., Lim, M., Hong, H., Shin, G. & Park, Y., 2008 Dec, Immunology of Diabetes V From Bench to Bedside. Blackwell Publishing Inc., p. 177-182 6 p. (Annals of the New York Academy of Sciences; vol. 1150).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations
2007

Transvascular delivery of small interfering RNA to the central nervous system

Kumar, P., Wu, H., McBride, J. L., Jung, K. E., Hee Kim, M., Davidson, B. L., Kyung Lee, S., Shankar, P. & Manjunath, N., 2007 Jul 7, In : Nature. 448, 7149, p. 39-43 5 p.

Research output: Contribution to journalArticle

857 Scopus citations
2006

A single siRNA suppresses fatal encephalitis induced by two different flaviviruses

Kumar, P., Sang, K. L., Shankar, P. & Manjunath, N., 2006 Apr 1, In : PLoS medicine. 3, 4, p. 505-514 10 p.

Research output: Contribution to journalArticle

140 Scopus citations

Interfering antiviral immunity: application, subversion, hope?

Manjunath, N., Kumar, P., Lee, S. K. & Shankar, P., 2006 Jul 1, In : Trends in Immunology. 27, 7, p. 328-335 8 p.

Research output: Contribution to journalReview article

19 Scopus citations

NFAT5 regulates HIV-1 in primary monocytes via a highly conserved long terminal repeat site

Ranjbar, S., Tsytsykova, A. V., Lee, S. K., Rajsbaum, R., Falvo, J. V., Lieberman, J., Shankar, P. & Goldfeld, A. E., 2006 Dec 1, In : PLoS Pathogens. 2, 12, p. 1176-1186 11 p.

Research output: Contribution to journalArticle

29 Scopus citations
2005

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

Song, E., Zhu, P., Lee, S. K., Chowdhury, D., Kussman, S., Dykxhoorn, D. M., Feng, Y., Palliser, D., Weiner, D. B., Shankar, P., Marasco, W. A. & Lieberman, J., 2005 Dec 9, In : Nature Biotechnology. 23, 6, p. 709-717 9 p.

Research output: Contribution to journalArticle

819 Scopus citations

Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV

Lee, S. K., Dykxhoorn, D. M., Kumar, P., Ranjbar, S., Song, E., Maliszewski, L. E., François-Bongarçon, V., Goldfeld, A., Swamy, N. M., Lieberman, J. & Shankar, P., 2005 Aug 1, In : Blood. 106, 3, p. 818-826 9 p.

Research output: Contribution to journalArticle

Open Access
79 Scopus citations
2004

Cross-clade CD8 T-cell responses to HIVIIIB and Chinese B′ and C/B′ viruses in North American and Chinese HIV-seropositive donors

François-Bongarcon, V., Feng, Y., Lee, S. K., Chen, G., Shankar, P., Liu, Y., Tao, X., Shao, Y. & Lieberman, J., 2004 Dec 1, In : Journal of Acquired Immune Deficiency Syndromes. 37, 4, p. 1435-1444 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Increased expression of the natural killer cell inhibitory receptor CD85j/ILT2 on antigen-specific effector CD8 T cells and its impact on CD8 T-cell function

Ince, M. N., Harnisch, B., Xu, Z., Lee, S. K., Lange, C., Moretta, L., Lederman, M. & Lieberman, J., 2004 Aug, In : Immunology. 112, 4, p. 531-542 12 p.

Research output: Contribution to journalArticle

41 Scopus citations
2003

Erratum: siRNA-directed inhibition of HIV-1 infection (Nature Medicine (2002) 8 (681-686))

Novina, C. D., Murray, M. F., Dykxhoorn, D. M., Beresford, P. J., Riess, J., Lee, S-K., Collman, R. G., Lieberman, J., Shankar, P. & Sharp, P. A., 2003 Nov 1, In : Nature Medicine. 9, 11, 1 p.

Research output: Contribution to journalComment/debate

4 Scopus citations

Interfering with disease: Opportunities and roadblocks to harnessing RNA interference

Lieberman, J., Song, E., Lee, S. K. & Shankar, P., 2003 Sep 1, In : Trends in Molecular Medicine. 9, 9, p. 397-403 7 p.

Research output: Contribution to journalReview article

92 Scopus citations

RNA interference targeting Fas protects mice from fulminant hepatitis

Song, E., Lee, S. K., Wang, J., Ince, N., Ouyang, N., Min, J., Chen, J., Shankar, P. & Lieberman, J., 2003 Mar 1, In : Nature Medicine. 9, 3, p. 347-351 5 p.

Research output: Contribution to journalArticle

989 Scopus citations

Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages

Song, E., Lee, S. K., Dykxhoorn, D. M., Novina, C., Zhang, D., Crawford, K., Cerny, J., Sharp, P. A., Lieberman, J., Manjunath, N. & Shankar, P., 2003 Jul, In : Journal of Virology. 77, 13, p. 7174-7181 8 p.

Research output: Contribution to journalArticle

Open Access
204 Scopus citations
2002

siRNA-directed inhibition of HIV-1 infection

Novina, C. D., Murray, M. F., Dykxhoorn, D. M., Beresford, P. J., Riess, J., Lee, S. K., Collman, R. G., Lieberman, J., Shankar, P. & Sharp, P. A., 2002 Jul, In : Nature Medicine. 8, 7, p. 681-686 6 p.

Research output: Contribution to journalArticle

711 Scopus citations

The functional CD8 T cell response to HIV becomes type-specific in progressive disease

Lee, S. K., Xu, Z., Lieberman, J. & Shankar, P., 2002 Nov, In : Journal of Clinical Investigation. 110, 9, p. 1339-1347 9 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations