• 5529 Citations
  • 41 h-Index
19992019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1999 2019

2019
1 Citation (Scopus)

A Helical Polypeptide-Based Potassium Ionophore Induces Endoplasmic Reticulum Stress-Mediated Apoptosis by Perturbing Ion Homeostasis

Lee, D. Y., Lee, S. H., Noh, I., Oh, E., Ryu, H., Ha, J. H., Jeong, S. D., Yoo, J., Jeon, T. J., Yun, C. O. & Kim, Y. C., 2019 Jul 17, In : Advanced Science. 6, 14, 1801995.

Research output: Contribution to journalArticle

Open Access
Potassium Ionophores
Ionophores
endoplasmic reticulum
homeostasis
Endoplasmic Reticulum Stress
Open Access
Glycyrrhizic Acid
HMGB1 Protein
Keloid
spheroids
Autophagy

Cryopreserved human natural killer cells exhibit potent antitumor efficacy against orthotopic pancreatic cancer through efficient tumor-homing and cytolytic ability

Oh, E., Min, B., Li, Y., Lian, C., Hong, J., Park, G. M., Yang, B., Cho, S. Y., Hwang, Y. K. & Yun, C. O., 2019 Jul 1, In : Cancers. 11, 7, 966.

Research output: Contribution to journalArticle

Open Access
Pancreatic Neoplasms
Natural Killer Cells
Neoplasms
gemcitabine
Extracellular Matrix

Development of apoptosis-inducing polypeptide via simultaneous mitochondrial membrane disruption and Ca2+ delivery

Ha, J. H., Lee, D. Y., Lee, S. H., Yun, C. O. & Kim, Y. C., 2019 Mar 1, In : Biomaterials. 197, p. 51-59 9 p.

Research output: Contribution to journalArticle

Polypeptides
Mitochondrial Membranes
Cell death
Apoptosis
Membranes
1 Citation (Scopus)

Mesenchymal stem cell-mediated delivery of an oncolytic adenovirus enhances antitumor efficacy in hepatocellular carcinoma

Rum Yoon, A., Hong, J. W., Li, Y., Shin, H. C., Lee, H., Kim, H. S. & Yun, C. O., 2019 Sep 1, In : Cancer Research. 79, 17, p. 4503-4514 12 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Adenoviridae
Hepatocellular Carcinoma
Neoplasms
Oncolytic Virotherapy

Oncolytic Ad co-expressing decorin and Wnt decoy receptor overcomes chemoresistance of desmoplastic tumor through degradation of ECM and inhibition of EMT

Li, Y., Hong, J. W., Jung, B. K., Oh, E. & Yun, C. O., 2019 Sep 10, In : Cancer Letters. 459, p. 15-29 15 p.

Research output: Contribution to journalArticle

Wnt Receptors
Decorin
Epithelial-Mesenchymal Transition
Adenoviridae
Extracellular Matrix

Physically crosslinked injectable hydrogels for long-term delivery of oncolytic adenoviruses for cancer treatment

Le, T. M. D., Jung, B. K., Li, Y., Duong, H. T. T., Nguyen, T. L., Hong, J. W., Yun, C. O. & Lee, D. S., 2019 Oct, In : Biomaterials Science. 7, 10, p. 4195-4207 13 p.

Research output: Contribution to journalArticle

Hydrogels
Oncology
Biocompatibility
Crosslinking
Tumors
Relaxin
Gene therapy
Genetic Therapy
Fibrosis
Tumors
1 Citation (Scopus)

Systemic administration of human mesenchymal stromal cells infected with polymer-coated oncolytic adenovirus induces efficient pancreatic tumor homing and infiltration

Na, Y., Nam, J. P., Hong, J. W., Oh, E., Shin, H. C., Kim, H. S., Kim, S. W. & Yun, C. O., 2019 Jul 10, In : Journal of Controlled Release. 305, p. 75-88 14 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Adenoviridae
Relaxin
Polymers
Neoplasms
2018
4 Citations (Scopus)
Telomerase
Glioblastoma
Adenoviridae
Apoptosis
Neoplasms
1 Citation (Scopus)

CARF enrichment promotes epithelial-mesenchymal transition via Wnt/β-catenin signaling: Its clinical relevance and potential as a therapeutic target

Kalra, R. S., Chaudhary, A., Yoon, A. R., Bhargava, P., Omar, A., Garg, S., Yun, C. O., Kaul, S. C. & Wadhwa, R., 2018 May 1, In : Oncogenesis. 7, 5, 39.

Research output: Contribution to journalArticle

Catenins
Epithelial-Mesenchymal Transition
Neoplasms
Therapeutics
Small Interfering RNA
5 Citations (Scopus)
Ubiquitin-Protein Ligases
Interferons
Lung Neoplasms
Growth
Proteins
5 Citations (Scopus)

Efficacy of combining ING4 and TRAIL genes in cancer-targeting gene virotherapy strategy: First evidence in preclinical hepatocellular carcinoma

El-Shemi, A. G., Ashshi, A. M., Oh, E., Jung, B. K., Basalamah, M., Alsaegh, A. & Yun, C. O., 2018 Jan 1, In : Gene Therapy. 25, 1, p. 54-65 12 p.

Research output: Contribution to journalArticle

Growth Inhibitors
Neoplasm Genes
Hepatocellular Carcinoma
Genes
Apoptosis
1 Citation (Scopus)

Emergence of ad-mediated combination therapy against cancer: What to expect?

Hong, J. W. & Yun, C. O., 2018 Jan 1, In : Current Cancer Drug Targets. 18, 2, p. 139-152 14 p.

Research output: Contribution to journalReview article

Adenoviridae
Neoplasms
Therapeutics
Virion
Immunotherapy

Epithelial-mesenchymal transition in keloid tissue

Yang, C. E., Moon, S. J., Kim, S. J., Lee, J. H., Yun, C. O., Lew, D. H. & Lee, W. J., 2018 Nov 1, In : Archives of Plastic Surgery. 45, 6, p. 600-601 2 p.

Research output: Contribution to journalComment/debate

Keloid
Epithelial-Mesenchymal Transition
4 Citations (Scopus)

HA/rGO/Pd nanocomposite thin film coating on SST 304 - Synthesize, characterization, and properties investigations

Yafei, H. F. S. G. A., Uzun, K., Musharavati, F., Zalnezhad, E., Hamouda, A. M. S., Yun, C. O. & Jaber, F., 2018 Apr 15, In : Journal of Alloys and Compounds. 741, p. 562-574 13 p.

Research output: Contribution to journalArticle

Nanocomposite films
Biocompatibility
Corrosion
Thin films
Coatings
1 Citation (Scopus)
Tumor Microenvironment
Adenoviridae
Hepatocellular Carcinoma
Neoplasms
Fetal Proteins
1 Citation (Scopus)

Identification and functional characterization of anti-metastasis and anti-angiogenic activities of triethylene glycol derivatives

Oh, E., Garg, S., Liu, Y., Afzal, S., Gao, R., Yun, C. O., Kaul, S. C. & Wadhwa, R., 2018 Jan 1, In : Frontiers in Oncology. 8, NOV, 552.

Research output: Contribution to journalArticle

Open Access
Neoplasm Metastasis
Catenins
Water
Vimentin
Matrix Metalloproteinases
7 Citations (Scopus)

Mathematical Modelling of the Interaction Between Cancer Cells and an Oncolytic Virus: Insights into the Effects of Treatment Protocols

Jenner, A. L., Yun, C. O., Kim, P. S. & Coster, A. C. F., 2018 Jun 1, In : Bulletin of Mathematical Biology. 80, 6, p. 1615-1629 15 p.

Research output: Contribution to journalArticle

Oncolytic Viruses
Clinical Protocols
Viruses
tumor
virus particle
1 Citation (Scopus)

Modelling combined virotherapy and immunotherapy: strengthening the antitumour immune response mediated by IL-12 and GM-CSF expression

Jenner, A. L., Yun, C. O., Yoon, A., Coster, A. C. F. & Kim, P. S., 2018 Jun 30, In : Letters in Biomathematics. 5, sup1, p. S99-S116

Research output: Contribution to journalArticle

Monocytes
Immunotherapy
Colony-Stimulating Factors
Interleukin
Immune Response
1 Citation (Scopus)

Modelling heterogeneity in viral-tumour dynamics: The effects of gene-attenuation on viral characteristics

Jenner, A., Yun, C. O., Yoon, A., Kim, P. S. & Coster, A. C. F., 2018 Oct 7, In : Journal of Theoretical Biology. 454, p. 41-52 12 p.

Research output: Contribution to journalArticle

Viruses
Attenuation
Virus
Tumors
Tumor
4 Citations (Scopus)

Potent antitumor effect of tumor microenvironment-targeted oncolytic adenovirus against desmoplastic pancreatic cancer

Li, Y., Hong, J. W., Oh, J. E., Yoon, A. R. & Yun, C. O., 2018 Jan 15, In : International Journal of Cancer. 142, 2, p. 392-413 22 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Pancreatic Neoplasms
Adenoviridae
Extracellular Matrix
Neoplasms
4 Citations (Scopus)

Profibrogenic effect of high-mobility group box protein-1 in human dermal fibroblasts and its excess in keloid tissues

Lee, W. J., Song, S. Y., Roh, H., Ahn, H. M., Na, Y., Kim, J., Lee, J. H. & Yun, C. O., 2018 Dec 1, In : Scientific reports. 8, 1, 8434.

Research output: Contribution to journalArticle

HMGB1 Protein
Keloid
Fibroblasts
Skin
Fibrosis
2017
5 Citations (Scopus)

Adenovirus-mediated decorin expression induces cancer cell death through activation of p53 and mitochondrial apoptosis

Yoon, A. R., Hong, J. W. & Yun, C. O., 2017 Jan 1, In : Oncotarget. 8, 44, p. 76666-76685 20 p.

Research output: Contribution to journalArticle

Decorin
Adenoviridae
Cell Death
Apoptosis
Neoplasms
9 Citations (Scopus)

A hydrogel matrix prolongs persistence and promotes specific localization of an oncolytic adenovirus in a tumor by restricting nonspecific shedding and an antiviral immune response

Jung, B. K., Oh, E., Hong, J. W., Lee, Y., Park, K. D. & Yun, C. O., 2017 Dec 1, In : Biomaterials. 147, p. 26-38 13 p.

Research output: Contribution to journalArticle

Hydrogel
Adenoviridae
Hydrogels
Antiviral Agents
Tumors
5 Citations (Scopus)

Conformation-switchable helical polypeptide eliciting selective pro-apoptotic activity for cancer therapy

Lee, D. Y., Lee, S. H., Na, Y., Noh, I., Ha, J. H., Yoo, J., Bang, H. B., Park, J. H., Jeong, K. J., Yun, C. O. & Kim, Y. C., 2017 Oct 28, In : Journal of Controlled Release. 264, p. 24-33 10 p.

Research output: Contribution to journalArticle

Peptides
Neoplasms
Mitochondrial Membranes
Therapeutics
Anions

Corrigendum to “Oncolytic adenovirus expressing relaxin (YDC002) enhances therapeutic efficacy of gemcitabine against pancreatic cancer” [Cancer Lett. 396 (2017) 155–166](S0304383517301738)(10.1016/j.canlet.2017.03.009)

Jung, K. H., Choi, I. K., Lee, H. S., Yan, H. H., Son, M. K., Ahn, H. M., Hong, J. W., Yun, C. O. & Hong, S. S., 2017 Sep 28, In : Cancer Letters. 404, 1 p.

Research output: Contribution to journalComment/debate

gemcitabine
Relaxin
Organized Financing
Pancreatic Neoplasms
Adenoviridae

Decoy Wnt receptor (sLRP6E1E2)-expressing adenovirus induces anti-fibrotic effect via inhibition of Wnt and TGF-β signaling

Lee, W. J., Lee, J. S., Ahn, H. M., Na, Y., Yang, C. E., Lee, J. H., Hong, J. & Yun, C. O., 2017 Dec 1, In : Scientific reports. 7, 1, 15070.

Research output: Contribution to journalArticle

Keloid
Adenoviridae
Fibroblasts
Catenins
Skin
2 Citations (Scopus)

Mortalin deficiency suppresses fibrosis and induces apoptosis in keloid spheroids

Lee, W. J., Ahn, H. M., Na, Y., Wadhwa, R. M., Hong, J. W. & Yun, C. O., 2017 Dec 1, In : Scientific reports. 7, 1, 12957.

Research output: Contribution to journalArticle

Keloid
Fibrosis
Apoptosis
mortalin
HSP70 Heat-Shock Proteins
10 Citations (Scopus)

Oncolytic adenovirus coexpressing interleukin-12 and decorin overcomes Treg-mediated immunosuppression inducing potent antitumor effects in a weakly immunogenic tumor model

Oh, E., Choi, I. K., Hong, J. W. & Yun, C. O., 2017 Jan 1, In : Oncotarget. 8, 3, p. 4730-4746 17 p.

Research output: Contribution to journalArticle

Decorin
Interleukin-12
Adenoviridae
Immunosuppression
Neoplasms
10 Citations (Scopus)

Oncolytic adenovirus expressing relaxin (YDC002) enhances therapeutic efficacy of gemcitabine against pancreatic cancer

Jung, K. H., Choi, I. K., Lee, H. S., Yan, H. H., Son, M. K., Ahn, H. M., Hong, J. W., Yun, C. O. & Hong, S. S., 2017 Jun 28, In : Cancer Letters. 396, p. 155-166 12 p.

Research output: Contribution to journalArticle

gemcitabine
Relaxin
Pancreatic Neoplasms
Adenoviridae
Extracellular Matrix
10 Citations (Scopus)

Optimized biodegradable polymeric reservoir-mediated local and sustained co-delivery of dendritic cells and oncolytic adenovirus co-expressing IL-12 and GM-CSF for cancer immunotherapy

Oh, E., Oh, J. E., Hong, J. W., Chung, Y. H., Lee, Y., Park, K. D., Kim, S. & Yun, C. O., 2017 Aug 10, In : Journal of Controlled Release. 259, p. 115-127 13 p.

Research output: Contribution to journalArticle

Interleukin-12
Granulocyte-Macrophage Colony-Stimulating Factor
Adenoviridae
Immunotherapy
Dendritic Cells
11 Citations (Scopus)

Relevance of mortalin to cancer cell stemness and cancer therapy

Yun, C. O., Bhargava, P., Na, Y., Lee, J. S., Ryu, J., Kaul, S. C. & Wadhwa, R., 2017 Feb 6, In : Scientific Reports. 7, 42016.

Research output: Contribution to journalArticle

Neoplasms
Therapeutics
Pharmaceutical Preparations
Tumor Suppressor Protein p53
Connexins
1 Citation (Scopus)

Safety profile of EGFR-targeted hybrid vector system composed of PAMAM dendrimer and oncolytic adenovirus

Yoon, A. R., Dayananda, K., Hong, J. & Yun, C. O., 2017 Mar 1, In : Journal of Thoracic Disease. 9, 3, p. E335-E336

Research output: Contribution to journalLetter

19 Citations (Scopus)

Selective disruption of an oncogenic mutant allele by CRISPR/Cas9 induces efficient tumor regression

Koo, T., Yoon, A. R., Cho, H. Y., Bae, S., Yun, C. O. & Kim, J. S., 2017 Jul 1, In : Nucleic Acids Research. 45, 13, p. 7897-7908 12 p.

Research output: Contribution to journalArticle

CRISPR-Associated Proteins
Clustered Regularly Interspaced Short Palindromic Repeats
Epidermal Growth Factor Receptor
Alleles
Mutation
Heme Oxygenase-1
Immunosuppressive Agents
Genes
Gene therapy
Paraquat
8 Citations (Scopus)

Synergistic antitumor effect mediated by a paclitaxel-conjugated polymeric micelle-coated oncolytic adenovirus

Dayananda, K., Lee, S. H., Hong, J. W., Choi, J. W., Nam, K., Chung, Y. H., Kim, S. W. & Yun, C. O., 2017 Nov 1, In : Biomaterials. 145, p. 207-222 16 p.

Research output: Contribution to journalArticle

Micelles
Paclitaxel
Adenoviridae
Tumors
Cells
2016
21 Citations (Scopus)

Anionic clay as the drug delivery vehicle: Tumor targeting function of layered double hydroxide- methotrexate nanohybrid in C33A orthotopic cervical cancer model

Choi, G., Piao, H., Aalothman, Z., Vinu, A., Yun, C. O. & Choy, J. H., 2016 Jan 20, In : International Journal of Nanomedicine. 11, p. 337-348 12 p.

Research output: Contribution to journalArticle

Drug delivery
Methotrexate
Uterine Cervical Neoplasms
Tumors
Clay
15 Citations (Scopus)

Antitumor effect and safety profile of systemically delivered oncolytic adenovirus complexed with EGFR-targeted PAMAM-based dendrimer in orthotopic lung tumor model

Yoon, A. R., Dayananda, K., Li, Y., Hong, J., Lee, W., Jung, S. J. & Yun, C. O., 2016 Jun 10, In : Journal of Controlled Release. 231, p. 2-16 15 p.

Research output: Contribution to journalArticle

Dendrimers
Epidermal Growth Factor Receptor
Adenoviridae
Safety
Lung
3 Citations (Scopus)

A single adenovirus-mediated relaxin delivery attenuates established liver fibrosis in rats

Kim, J. K., Lee, J. I., Paik, Y. H., Yun, C. O., Chang, H. Y., Lee, S. Y. & Lee, K. S., 2016 Jan 1, In : Journal of Gene Medicine. 18, 1-3, p. 16-26 11 p.

Research output: Contribution to journalArticle

Relaxin
Thioacetamide
Adenoviridae
Liver Cirrhosis
Collagen
54 Citations (Scopus)

Biodegradable Inorganic Nanovector: Passive versus Active Tumor Targeting in siRNA Transportation

Park, D. H., Cho, J., Kwon, O. J., Yun, C. O. & Choy, J. H., 2016 Mar 24, In : Angewandte Chemie - International Edition. 55, 14, p. 4582-4586 5 p.

Research output: Contribution to journalArticle

Small Interfering RNA
Tumors
Genes
Folic Acid
Clathrin
9 Citations (Scopus)

CHIP-mediated degradation of transglutaminase 2 negatively regulates tumor growth and angiogenesis in renal cancer

Min, B., Park, H., Lee, S., Li, Y., Choi, J. M., Lee, J. Y., Kim, J., Choi, Y. D., Kwon, Y. G., Lee, H. W., Bae, S. C., Yun, C. O. & Chung, K. C., 2016 Jul 14, In : Oncogene. 35, 28, p. 3718-3728 11 p.

Research output: Contribution to journalArticle

Kidney Neoplasms
Proteolysis
Growth
Neoplasms
Proteins
12 Citations (Scopus)

Combined therapy with oncolytic adenoviruses encoding TRAIL and IL-12 genes markedly suppressed human hepatocellular carcinoma both in vitro and in an orthotopic transplanted mouse model

El-Shemi, A. G., Ashshi, A. M., Na, Y., Li, Y., Basalamah, M., Al-Allaf, F. A., Oh, E., Jung, B. K. & Yun, C. O., 2016 May 6, In : Journal of Experimental and Clinical Cancer Research. 35, 1, 353.

Research output: Contribution to journalArticle

Interleukin-12
Adenoviridae
Hepatocellular Carcinoma
Genes
Therapeutics
12 Citations (Scopus)

Effect of function-enhanced mesenchymal stem cells infected with decorin-expressing adenovirus on hepatic fibrosis

Jang, Y. O., Cho, M. Y., Yun, C. O., Baik, S. K., Park, K. S., Cha, S. K., Chang, S. J., Kim, M. Y., Lim, Y. L. & Kwon, S. O., 2016 Jan 1, In : Stem Cells Translational Medicine. 5, 9, p. 1247-1256 10 p.

Research output: Contribution to journalArticle

Decorin
Mesenchymal Stromal Cells
Adenoviridae
Fibrosis
Liver
16 Citations (Scopus)

Effects of human mesenchymal stem cells transduced with superoxide dismutase on imiquimod-induced psoriasis-like skin inflammation in mice

Sah, S. K., Park, K. H., Yun, C. O., Kang, K. S. & Kim, T. Y., 2016 Feb 10, In : Antioxidants and Redox Signaling. 24, 5, p. 233-248 16 p.

Research output: Contribution to journalArticle

imiquimod
Stem cells
Mesenchymal Stromal Cells
Psoriasis
Superoxide Dismutase
Interleukin-12
Adenoviridae
Hepatocellular Carcinoma
Theoretical Models
Research
9 Citations (Scopus)

Evolving lessons on nanomaterial-coated viral vectors for local and systemic gene therapy

Dayananda, K., Yoon, A. R., Hong, J., Kim, S. W. & Yun, C. O., 2016 Jul 1, In : Nanomedicine. 11, 13, p. 1689-1713 25 p.

Research output: Contribution to journalReview article

Gene therapy
Nanostructures
Nanostructured materials
Genetic Therapy
Viral Tropism
5 Citations (Scopus)

Hepatocyte growth factor-expressing adenovirus upregulates matrix metalloproteinase-1 expression in keloid fibroblasts

Jeon, Y. R., Ahn, H. M., Choi, I. K., Yun, C. O., Rah, D. K., Lew, D. H. & Lee, W. J., 2016 Mar 1, In : International Journal of Dermatology. 55, 3, p. 356-361 6 p.

Research output: Contribution to journalArticle

Keloid
Matrix Metalloproteinase 1
Hepatocyte Growth Factor
Adenoviridae
Up-Regulation
3 Citations (Scopus)

Human relaxin gene expression delivered by bioreducible dendrimer polymer for post-infarct cardiac remodeling in rats

Lee, Y. S., Choi, J. W., Oh, J. E., Yun, C. O. & Kim, S. W., 2016 Aug 1, In : Biomaterials. 97, p. 164-175 12 p.

Research output: Contribution to journalArticle

Relaxin
Dendrimers
Gene expression
Extracellular Matrix
Rats
32 Citations (Scopus)

Mild Hyperthermia Induced by Gold Nanorod-Mediated Plasmonic Photothermal Therapy Enhances Transduction and Replication of Oncolytic Adenoviral Gene Delivery

Jung, B. K., Lee, Y. K., Hong, J., Ghandehari, H. & Yun, C. O., 2016 Nov 22, In : ACS nano. 10, 11, p. 10533-10543 11 p.

Research output: Contribution to journalArticle

adenoviruses
hyperthermia
Nanorods
Gold
genes