• 6121 Citations
  • 42 h-Index
19992020

Research output per year

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Research Output

2020

Bioinformatics and molecular insights to anti-metastasis activity of triethylene glycol derivatives

Malik, V., Garg, S., Afzal, S., Dhanjal, J. K., Yun, C. O., Kaul, S. C., Sundar, D. & Wadhwa, R., 2020 Aug 1, In : International Journal of Molecular Sciences. 21, 15, p. 1-23 23 p., 5463.

Research output: Contribution to journalArticle

Open Access

Chiral Supraparticles for Controllable Nanomedicine

Yeom, J., Guimaraes, P. P. G., Ahn, H. M., Jung, B. K., Hu, Q., McHugh, K., Mitchell, M. J., Yun, C. O., Langer, R. & Jaklenec, A., 2020 Jan 1, In : Advanced Materials. 32, 1, 1903878.

Research output: Contribution to journalArticle

7 Scopus citations

CRISPR-Cas12a with an oAd Induces Precise and Cancer-Specific Genomic Reprogramming of EGFR and Efficient Tumor Regression

Yoon, A. R., Jung, B. K., Choi, E., Chung, E., Hong, J. W., Kim, J. S., Koo, T. & Yun, C. O., 2020, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

Del-1, an Endogenous Inhibitor of TGF-β Activation, Attenuates Fibrosis

Kim, D. Y., Lee, S. H., Fu, Y., Jing, F., Kim, W. Y., Hong, S. B., Song, J. A., Choe, H., Ryu, H. J., Kim, M., Lim, D., Kim, M. S., Yun, C. O., Lee, T., Hyun, H. & Choi, E. Y., 2020 Feb 7, In : Frontiers in immunology. 11, 68.

Research output: Contribution to journalArticle

Open Access

Dickkopf 2-Expressing Adenovirus Increases the Survival of Random-Pattern Flaps and Promotes Vasculogenesis in a Rat Model

Choi, S. W., Jeon, Y. R., Baek, W., Yun, C. O., Roh, T. S. & Lee, W. J., 2020 May 1, In : Annals of plastic surgery. 84, 5, p. 588-594 7 p.

Research output: Contribution to journalArticle

Inhibition of Wnt signaling pathway suppresses radiation-induced dermal fibrosis

Lee, D. W., Lee, W. J., Cho, J., Yun, C. O., Roh, H., Chang, H. P., Roh, T. S., Lee, J. H. & Lew, D. H., 2020 Dec 1, In : Scientific reports. 10, 1, 13594.

Research output: Contribution to journalArticle

Open Access

Mesenchymal stem cells used as carrier cells of oncolytic adenovirus results in enhanced oncolytic virotherapy

Mahasa, K. J., de Pillis, L., Ouifki, R., Eladdadi, A., Maini, P., Yoon, A. R. & Yun, C. O., 2020 Dec 1, In : Scientific reports. 10, 1, 425.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Nose-to-Brain Delivery of Cancer-Targeting Paclitaxel-Loaded Nanoparticles Potentiates Antitumor Effects in Malignant Glioblastoma

Ullah, I., Chung, K., Bae, S., Li, Y., Kim, C., Choi, B., Nam, H. Y., Kim, S. H., Yun, C. O., Lee, K. Y., Kumar, P. & Lee, S. K., 2020 Apr 6, In : Molecular Pharmaceutics. 17, 4, p. 1193-1204 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Optimising hydrogel release profiles for viro-immunotherapy using oncolytic adenovirus expressing IL-12 and GM-CSF with immature dendritic cells

Jenner, A. L., Frascoli, F., Yun, C. O. & Kim, P. S., 2020 Apr 1, In : Applied Sciences (Switzerland). 10, 8, 2872.

Research output: Contribution to journalArticle

Open Access

Relaxin-expressing oncolytic adenovirus induces remodeling of physical and immunological aspects of cold tumor to potentiate PD-1 blockade

Jung, B. K., Ko, H. Y., Kang, H., Hong, J., Ahn, H. M., Na, Y., Kim, H., Kim, J. S. & Yun, C. O., 2020 Aug 4, In : Journal for ImmunoTherapy of Cancer. 8, 2, e000763.

Research output: Contribution to journalArticle

Open Access

Sustained release of decoy wnt receptor (SLRP6E1E2)-expressing adenovirus using gel-encapsulation for scar remodeling in pig model

Yang, C. E., Choi, S., Lee, J. H., Kang, E. H., Ahn, H. M., Roh, T. S., Yun, C. O. & Lee, W. J., 2020 Mar 2, In : International Journal of Molecular Sciences. 21, 6, 2242.

Research output: Contribution to journalArticle

Open Access
2019

A Helical Polypeptide-Based Potassium Ionophore Induces Endoplasmic Reticulum Stress-Mediated Apoptosis by Perturbing Ion Homeostasis

Lee, D. Y., Lee, S. H., Noh, I., Oh, E., Ryu, H., Ha, J. H., Jeong, S. D., Yoo, J., Jeon, T. J., Yun, C. O. & Kim, Y. C., 2019 Jul 17, In : Advanced Science. 6, 14, 1801995.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access
2 Scopus citations

Cryopreserved human natural killer cells exhibit potent antitumor efficacy against orthotopic pancreatic cancer through efficient tumor-homing and cytolytic ability

Oh, E., Min, B., Li, Y., Lian, C., Hong, J., Park, G. M., Yang, B., Cho, S. Y., Hwang, Y. K. & Yun, C. O., 2019 Jul, In : Cancers. 11, 7, 966.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Development of apoptosis-inducing polypeptide via simultaneous mitochondrial membrane disruption and Ca2+ delivery

Ha, J. H., Lee, D. Y., Lee, S. H., Yun, C. O. & Kim, Y. C., 2019 Mar, In : Biomaterials. 197, p. 51-59 9 p.

Research output: Contribution to journalArticle

Effect of relaxin expression from an alginate gel-encapsulated adenovirus on scar remodeling in a pig model

Yun, I. S., Kang, E., Ahn, H. M., Kim, Y. O., Rah, D. K., Roh, T. S., Lee, W. J. & Yun, C. O., 2019 Sep, In : Yonsei Medical Journal. 60, 9, p. 854-863 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Mesenchymal stem cell-mediated delivery of an oncolytic adenovirus enhances antitumor efficacy in hepatocellular carcinoma

Rum Yoon, A., Hong, J. W., Li, Y., Shin, H. C., Lee, H., Kim, H. S. & Yun, C. O., 2019 Sep 1, In : Cancer Research. 79, 17, p. 4503-4514 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Oncolytic Ad co-expressing decorin and Wnt decoy receptor overcomes chemoresistance of desmoplastic tumor through degradation of ECM and inhibition of EMT

Li, Y., Hong, J. W., Jung, B. K., Oh, E. & Yun, C. O., 2019 Sep 10, In : Cancer Letters. 459, p. 15-29 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Physically crosslinked injectable hydrogels for long-term delivery of oncolytic adenoviruses for cancer treatment

Le, T. M. D., Jung, B. K., Li, Y., Duong, H. T. T., Nguyen, T. L., Hong, J. W., Yun, C. O. & Lee, D. S., 2019 Oct, In : Biomaterials Science. 7, 10, p. 4195-4207 13 p.

Research output: Contribution to journalArticle

5 Scopus citations
2 Scopus citations

Systemic administration of human mesenchymal stromal cells infected with polymer-coated oncolytic adenovirus induces efficient pancreatic tumor homing and infiltration

Na, Y., Nam, J. P., Hong, J. W., Oh, E., Shin, H. C., Kim, H. S., Kim, S. W. & Yun, C. O., 2019 Jul 10, In : Journal of Controlled Release. 305, p. 75-88 14 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018
10 Scopus citations

CARF enrichment promotes epithelial-mesenchymal transition via Wnt/β-catenin signaling: Its clinical relevance and potential as a therapeutic target

Kalra, R. S., Chaudhary, A., Yoon, A. R., Bhargava, P., Omar, A., Garg, S., Yun, C. O., Kaul, S. C. & Wadhwa, R., 2018 May 1, In : Oncogenesis. 7, 5, 39.

Research output: Contribution to journalArticle

6 Scopus citations
12 Scopus citations

Efficacy of combining ING4 and TRAIL genes in cancer-targeting gene virotherapy strategy: First evidence in preclinical hepatocellular carcinoma

El-Shemi, A. G., Ashshi, A. M., Oh, E., Jung, B. K., Basalamah, M., Alsaegh, A. & Yun, C. O., 2018 Jan 1, In : Gene Therapy. 25, 1, p. 54-65 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Emergence of ad-mediated combination therapy against cancer: What to expect?

Hong, J. W. & Yun, C. O., 2018 Jan 1, In : Current Cancer Drug Targets. 18, 2, p. 139-152 14 p.

Research output: Contribution to journalReview article

1 Scopus citations

Epithelial-mesenchymal transition in keloid tissue

Yang, C. E., Moon, S. J., Kim, S. J., Lee, J. H., Yun, C. O., Lew, D. H. & Lee, W. J., 2018 Nov, In : Archives of Plastic Surgery. 45, 6, p. 600-601 2 p.

Research output: Contribution to journalComment/debate

HA/rGO/Pd nanocomposite thin film coating on SST 304 - Synthesize, characterization, and properties investigations

Yafei, H. F. S. G. A., Uzun, K., Musharavati, F., Zalnezhad, E., Hamouda, A. M. S., Yun, C. O. & Jaber, F., 2018 Apr 15, In : Journal of Alloys and Compounds. 741, p. 562-574 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
3 Scopus citations

Identification and functional characterization of anti-metastasis and anti-angiogenic activities of triethylene glycol derivatives

Oh, E., Garg, S., Liu, Y., Afzal, S., Gao, R., Yun, C. O., Kaul, S. C. & Wadhwa, R., 2018, In : Frontiers in Oncology. 8, NOV, 552.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Mathematical Modelling of the Interaction Between Cancer Cells and an Oncolytic Virus: Insights into the Effects of Treatment Protocols

Jenner, A. L., Yun, C. O., Kim, P. S. & Coster, A. C. F., 2018 Jun 1, In : Bulletin of Mathematical Biology. 80, 6, p. 1615-1629 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

Modelling combined virotherapy and immunotherapy: strengthening the antitumour immune response mediated by IL-12 and GM-CSF expression

Jenner, A. L., Yun, C. O., Yoon, A., Coster, A. C. F. & Kim, P. S., 2018 Jun 30, In : Letters in Biomathematics. 5, sup1, p. S99-S116

Research output: Contribution to journalArticle

3 Scopus citations

Modelling heterogeneity in viral-tumour dynamics: The effects of gene-attenuation on viral characteristics

Jenner, A., Yun, C. O., Yoon, A., Kim, P. S. & Coster, A. C. F., 2018 Oct 7, In : Journal of Theoretical Biology. 454, p. 41-52 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Potent antitumor effect of tumor microenvironment-targeted oncolytic adenovirus against desmoplastic pancreatic cancer

Li, Y., Hong, J. W., Oh, J. E., Yoon, A. R. & Yun, C. O., 2018 Jan 15, In : International Journal of Cancer. 142, 2, p. 392-413 22 p.

Research output: Contribution to journalArticle

6 Scopus citations

Profibrogenic effect of high-mobility group box protein-1 in human dermal fibroblasts and its excess in keloid tissues

Lee, W. J., Song, S. Y., Roh, H., Ahn, H. M., Na, Y., Kim, J., Lee, J. H. & Yun, C. O., 2018 Dec 1, In : Scientific reports. 8, 1, 8434.

Research output: Contribution to journalArticle

7 Scopus citations
2017

Adenovirus-mediated decorin expression induces cancer cell death through activation of p53 and mitochondrial apoptosis

Yoon, A. R., Hong, J. W. & Yun, C. O., 2017, In : Oncotarget. 8, 44, p. 76666-76685 20 p.

Research output: Contribution to journalArticle

10 Scopus citations

A hydrogel matrix prolongs persistence and promotes specific localization of an oncolytic adenovirus in a tumor by restricting nonspecific shedding and an antiviral immune response

Jung, B. K., Oh, E., Hong, J. W., Lee, Y., Park, K. D. & Yun, C. O., 2017 Dec, In : Biomaterials. 147, p. 26-38 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Conformation-switchable helical polypeptide eliciting selective pro-apoptotic activity for cancer therapy

Lee, D. Y., Lee, S. H., Na, Y., Noh, I., Ha, J. H., Yoo, J., Bang, H. B., Park, J. H., Jeong, K. J., Yun, C. O. & Kim, Y. C., 2017 Oct 28, In : Journal of Controlled Release. 264, p. 24-33 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Corrigendum to “Oncolytic adenovirus expressing relaxin (YDC002) enhances therapeutic efficacy of gemcitabine against pancreatic cancer” [Cancer Lett. 396 (2017) 155–166](S0304383517301738)(10.1016/j.canlet.2017.03.009)

Jung, K. H., Choi, I. K., Lee, H. S., Yan, H. H., Son, M. K., Ahn, H. M., Hong, J. W., Yun, C. O. & Hong, S. S., 2017 Sep 28, In : Cancer Letters. 404, 1 p.

Research output: Contribution to journalComment/debate

Decoy Wnt receptor (sLRP6E1E2)-expressing adenovirus induces anti-fibrotic effect via inhibition of Wnt and TGF-β signaling

Lee, W. J., Lee, J. S., Ahn, H. M., Na, Y., Yang, C. E., Lee, J. H., Hong, J. & Yun, C. O., 2017 Dec 1, In : Scientific reports. 7, 1, 15070.

Research output: Contribution to journalArticle

2 Scopus citations

Mortalin deficiency suppresses fibrosis and induces apoptosis in keloid spheroids

Lee, W. J., Ahn, H. M., Na, Y., Wadhwa, R. M., Hong, J. W. & Yun, C. O., 2017 Dec 1, In : Scientific reports. 7, 1, 12957.

Research output: Contribution to journalArticle

4 Scopus citations

Oncolytic adenovirus coexpressing interleukin-12 and decorin overcomes Treg-mediated immunosuppression inducing potent antitumor effects in a weakly immunogenic tumor model

Oh, E., Choi, I. K., Hong, J. W. & Yun, C. O., 2017 Jan 1, In : Oncotarget. 8, 3, p. 4730-4746 17 p.

Research output: Contribution to journalArticle

19 Scopus citations

Oncolytic adenovirus expressing relaxin (YDC002) enhances therapeutic efficacy of gemcitabine against pancreatic cancer

Jung, K. H., Choi, I. K., Lee, H. S., Yan, H. H., Son, M. K., Ahn, H. M., Hong, J. W., Yun, C. O. & Hong, S. S., 2017 Jun 28, In : Cancer Letters. 396, p. 155-166 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Optimized biodegradable polymeric reservoir-mediated local and sustained co-delivery of dendritic cells and oncolytic adenovirus co-expressing IL-12 and GM-CSF for cancer immunotherapy

Oh, E., Oh, J. E., Hong, J. W., Chung, Y. H., Lee, Y., Park, K. D., Kim, S. & Yun, C. O., 2017 Aug 10, In : Journal of Controlled Release. 259, p. 115-127 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Relevance of mortalin to cancer cell stemness and cancer therapy

Yun, C. O., Bhargava, P., Na, Y., Lee, J. S., Ryu, J., Kaul, S. C. & Wadhwa, R., 2017 Feb 6, In : Scientific reports. 7, 42016.

Research output: Contribution to journalArticle

17 Scopus citations

Safety profile of EGFR-targeted hybrid vector system composed of PAMAM dendrimer and oncolytic adenovirus

Yoon, A. R., Kasala, D., Hong, J. & Yun, C. O., 2017 Mar 1, In : Journal of Thoracic Disease. 9, 3, p. E335-E336

Research output: Contribution to journalLetter

1 Scopus citations

Selective disruption of an oncogenic mutant allele by CRISPR/Cas9 induces efficient tumor regression

Koo, T., Yoon, A. R., Cho, H. Y., Bae, S., Yun, C. O. & Kim, J. S., 2017 Jul 1, In : Nucleic Acids Research. 45, 13, p. 7897-7908 12 p.

Research output: Contribution to journalArticle

27 Scopus citations
1 Scopus citations

Synergistic antitumor effect mediated by a paclitaxel-conjugated polymeric micelle-coated oncolytic adenovirus

Kasala, D., Lee, S. H., Hong, J. W., Choi, J. W., Nam, K., Chung, Y. H., Kim, S. W. & Yun, C. O., 2017 Nov, In : Biomaterials. 145, p. 207-222 16 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Anionic clay as the drug delivery vehicle: Tumor targeting function of layered double hydroxide- methotrexate nanohybrid in C33A orthotopic cervical cancer model

Choi, G., Piao, H., Aalothman, Z., Vinu, A., Yun, C. O. & Choy, J. H., 2016 Jan 20, In : International Journal of Nanomedicine. 11, p. 337-348 12 p.

Research output: Contribution to journalArticle

28 Scopus citations